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Sure-Handed Alchemy

Source Alchemy Manual pg. 5
Your steady hand increases your chances of success with spontaneous alchemy and reduces your number of mishaps.

Prerequisites: Craft (alchemy) 3 ranks.

Benefit: When attempting Craft (alchemy) checks to create items using spontaneous alchemy, you gain a cumulative +1 circumstance bonus for each distinct reagent called for by the recipe. A failed Craft (alchemy) check results in a mishap only on a natural 1. Finally, you take no penalties on Craft (alchemy) checks when using improvised equipment to create items using spontaneous alchemy.